Vav2 GEF protein (human recomb. DH domain, 6xHis tagged) Vav2全球环境基金蛋白（人类重组。DH域，6xHis标记）

2020-06-12 11:19:33  浏览：668  作者：管理员

Product Uses

Vav2 protein is a guanine exchange factor with selectivity for Rac1, which mediates Rac1 activation under a variety of conditions and has been associated with gastric tumors as well as cellular volume control and neurite extension (reviewed in 1, 2, 3).

  • Study inhibitors of Vav2 GTP/GDP exchange activity

  • Identification of Vav2 DH domain binding proteins

  • Study of Vav2 GEF activity with different GTPases

References
1. Tan B.B. et al. 2017. Up-regulated Vav2 in gastric cancer tissues promotes tumor invasion and metastasis. Tumour Biol. 39(5):1010428317698392.
2. Salin-Cantegrel A. et al 2013. Potassium-chloride cotransporter 3 interacts with Vav2 to synchronize the cell volume decrease response with cell protrusion dynamics. PLoS One. 8(5):e65294.
3. Moon M.S. et al. 2010. Balanced Vav2 GEF activity regulates neurite outgrowth and branching in vitro and in vivo. Mol Cell Neurosci. 44(2):118-28.


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