Vav1 GEF protein (human recomb. DHPHC1 domain Y174D mutant, 6xHis tagged) Vav1 GEF蛋白（人类重组。DHPHC1结构域Y174D突变体，6xHis标记）

2020-06-12 11:18:18  浏览：762  作者：管理员

Product Uses

Vav1 protein is a guanine exchange factor with selectivity for Rac1, which mediates Rac1 activation under a variety of conditions and has been associated with multiple diseases for example autoimmune deficiency and esophageal squamous cell carcinoma  (reviewed in 1, 2, 3).

  • Study inhibitors of Vav1 GTP/GDP exchange activity

  • Identification of Vav1 DHPHC1 domain binding proteins

  • Study of Vav1 GEF activity with different GTPases

References
1. Zhu X. et al. 2017. Vav1 expression is increased in esophageal squamous cell carcinoma and indicates poor prognosis. Biochem Biophys Res Commun., 486(2):571-576. 
2. Guerreiro-Cacais A.O. et al. 2017. VAV1 regulates experimental autoimmune arthritis and is associated with anti-CCP negative rheumatoid arthritis. Genes Immun. 18(1):48-56.
3. Razanadrakoto L. et al. 2015. Mutation of Vav1 adaptor region reveals a new oncogenic activation. Oncotarget. 10; 6(4):2524-37.


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