通用领域 生物医药 Ras-GRF GEF protein (human recomb. CDC25 domain, MBP tagged) Ras-GRF-GEF蛋白(人类重组。CDC25域,MBP标记)

2020-06-12 10:49:55  浏览:867  作者:管理员

Product Uses

RasGRF1 is a guanine exchange factor with selectivity for H-, K-, N- and R-Ras, which mediates Ras isoform activation under a variety of conditions and has been associated with multiple diseases (reviewed in 1, 2).

  • Study inhibitors of RasGRF GTP/GDP exchange activity

  • Identification of RasGRF Cdc25 domain binding proteins

  • Study of RasGRF GEF activity with different GTPases

References
1. Fernandez-Medarde A. and Santos E. 2011. Biochim. Biophys. Acta. 1815, 170-188.
2. Quilliam L.A. et al. 2002. Prog. Nucleic Acid Res. Mol. Biol. 71, 391-444.


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