Product Uses
Vav2 protein is a guanine exchange factor with selectivity for Rac1, which mediates Rac1 activation under a variety of conditions and has been associated with gastric tumors as well as cellular volume control and neurite extension (reviewed in 1, 2, 3).
Study inhibitors of Vav2 GTP/GDP exchange activity
Identification of Vav2 DH domain binding proteins
Study of Vav2 GEF activity with different GTPases
References1. Tan B.B. et al. 2017. Up-regulated Vav2 in gastric cancer tissues promotes tumor invasion and metastasis. Tumour Biol. 39(5):1010428317698392.2. Salin-Cantegrel A. et al 2013. Potassium-chloride cotransporter 3 interacts with Vav2 to synchronize the cell volume decrease response with cell protrusion dynamics. PLoS One. 8(5):e65294.3. Moon M.S. et al. 2010. Balanced Vav2 GEF activity regulates neurite outgrowth and branching in vitro and in vivo. Mol Cell Neurosci. 44(2):118-28.
